Classic drug targets

Drug targets for amyloidosis.

The amyloid hypothesis indicates that protein misfolding is at the root of many neurodegenerative disorders. Small molecules targeting the formation, clearance, aggregation to toxic oligomers or SOD (superoxide dismutase)-like activities of Abeta (amyloid beta-peptide) 1-42 have provided encouraging candidates for AD (Alzheimer's disease) medicines in animal models, although none have yet prove...

Anti-hiv Drug Targets

ANTI-HIV DRUG TARGETS HIV is a retrovirus, with a simple structure described in Box 1, and illustrated in Figure 1. It contains genes coding for a number of unique viral enzymes, required at different stages of the virus’s life cycle (see Box 2 and Figure 2). One of these is reverse transcriptase, required to make copies of the viral genes once it has infected human cells. Another is HIV protea...

Proteases as drug targets.

The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials. Mindful of the MMP inhibitor experience, this chapt...

Anticancer drug targets: approaching angiogenesis.

Glycosyltransferases as Potential Drug Targets

Copyright: © 2013 Sun XL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Glycoconjugates, existing as glycoproteins, glycolipids and proteoglycans on cell surface, are involved in many biological processes, s...